REBALANCE - Mechanisms of focused ultRasound mEdiated BrAin cLeAniNg Coupled with enhanced mEchanosensation

Focused ultrasound (FUS) is a non-invasive, ground-breaking technique suggested for the treatment of Alzheimer’s disease. REBALANCE aims to discover the key cellular targets and molecular mechanisms underlying FUS-induced brain cleaning and therapeutic efficacy in Alzheimer’s disease. The combination of human-based models and state-of-the-art animal models bridges the preclinical mechanistic findings to clinical data and provide biomarkers indicative of therapeutic benefit. Continuous analysis of ethical issues will allow us to identify ethical challenges in the research and development process from the point of view of different stakeholders, to minimize ethical risks and to involve patient organizations in the dialogue. Combined these efforts will lead to efficient clinical translation of the preclinical findings and towards more efficient treatment of patients with Alzheimer’s disease. ICPM group of researchers leads and implements in collaboration with consortium partners work package 6 of REBALANCE project “Mapping of ethical risks”.

Project duration: 01.04.2023. - 31.12.2026.

Project ID No.: ES RTD/2023/22

Total funding: 300 000 EUR

Project scientific manager: Signe Mežinska