Academic CentreInternationally cited publications
Scientific articles published in global citation index lists (PubMed, Scopus, Web of Science, Google Scholar, etc.)
1. Nakhleh M. K., Amal H., Jeries R., Broza Y., M Aboud … Leja M. Diagnosis and Classification of 17 Diseases from 1404 Subjects via Pattern Analysis of Exhaled Molecules. ACS Nano. 2017;Jan 24;11(1):112-125.
2. Leja M, Camargo M.C., Polaka I., Isajevs S., Liepniece-Karele I., Janciauskas D., Rudzite D., Kikuste I., Vanags A., Kojalo I., Folkmanis V., Kirsners A., ... [et al.] Detection of gastric atrophy by circulating pepsinogens: A comparison of three assays. Helicobacter. 2017;22(4).
3. Petkevicius V., Salteniene V., Juzenas S., Wex T., Link A., Leja M., Steponaitiene R., Skieceviciene J., Kupcinskas L., Jonaitis L., Kiudelis G., Malfertheiner P., Kupcinskas J. Polymorphisms of microRNA target genes IL12B, INSR, CCND1 and IL10 in gastric Cancer. World Journal of Gastroenterology. 2017; 23(19): 3480-3487.
4. 2015 European Society of Coloproctology collaborating group; Leja M, et.al. The relationship between method of anastomosis and anastomotic failure after right hemicolectomy and ileo-caecal resection: an international snapshot audit. Colorectal Disease. 2017; 19(8): e296-e311
5. Kontsevaya I., Nikolayevskyy V., Kovalyov A., Ignatyeva O., Sadykhova A., Simak T., Tikhonova O., Dubrovskaya Y., Vasiliauskiene E., Davidaviciene E., Skenders G., Makurina O., Balabanova Y., Drobniewski F. Tuberculosis cases caused by heterogeneous infection in Eastern Europe and their influence on outcomes. Journal of molecular epidemiology and evolutionary genetics in infectious diseases. MEEGID .2017; 48:76-82
6. Malfertheiner P., Megraud F., Leja M, et.al. Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report. Gut.2017. 66(1):6-30.
7. Meistere I., Werner S., Zayakin P., Siliņa K., Rulle U., Pismennaja A., Šantare D., Kikuste I., Isajevs S., Leja M., Kupčinskas L., Kupčinskas J., Jonaitis L., Wu CY., Brenner H., Linē A., Kalniņa Z. The Prevalence of Cancer-Associated Autoantibodies in Patients with Gastric Cancer and Progressive Grades of Premalignant Lesions. Cancer Epidemiol. Biomarkers Prev. 2017. 26(10):1564-1574.
8. Leja M., Park JY., Murillo R., Liepniece-Karele I., Isajevs S., Kikuste I., Rudzite D., Krike P., Parshutin S., Polaka I., Kirsners A., Santare D., Folkmanis V., Daugule I., Plummer M., Herrero R. Multicentric randomised study of Helicobacter pylori eradication and pepsinogen testing for prevention of gastric cancer mortality: the GISTAR study. BMJ Open.2017. 7(8):e016999.
9. Gudra D., Fridmanis D., Klovins J., Skenders G., Silamikelis I., Radovica-Spalvina I., Peculis R., Kalnina i., Elbere I., Hultcrantz R., Leja M., Engstrand L. FIT test-systems for mega-scale gut microbiome testing. Annals of Oncology, Volume 28, Issue suppl_3, 1 June 2017, mdx261.032, doi.org/10.1093/annonc/mdx261.032
10. Sjomina O., Heluwaert F., Moussata D., Leja M. Helicobacter pylori infection and nonmalignant diseases. PMID: 28891136 DOI: 10.1111/hel.12408
In Latvian scientific publications
LZA Vēstis, u.c.
1. Leja M. Helikobaktērija - draugs vai ienaidnieks? Latvijas Ārsts, 2017: decembris, 34-39.
2. Leja M., Lašina I., Šitikova I., Krastiņa S., Petkeviča Ģ. Cik pareizi H.pylori eradikācijas terapiju izvēlas Latvijas ģimenes ārsti un gastroenterologi? Latvijas Ārsts, 2017: decembris, 40-44.
3. Apine I., Pokrotnieks J., Leja M., Atteka S., Krumina G. MRI Apparent Diffusion Coefficient Values in Collapsed and Distended Small Bowel Loops and their Potential Importance for excluding Inflammatory Bowel Disease: A Study in Health Subjects. Acta Chirurgica Latviensis, 2016: 1, 23-30.
Most significant abstracts at international conferences
1. M. Leja , A. Rudule , J. Young Park , R. Murillo, I. Liepniece-Karele , S. Isajevs , I. Kikuste, D. Rudzite, P.Krike, S. Parshutin, I. Polaka, A. Kirsners , D. Santare, I. Daugule , R. Herrero. Multicentric randomized study of H. pylori eradication and pepsinogen testing for prevention of gastric cancer mortality (GISTAR): preliminary results of the pilot. XII International Gastric Cancer Congress. 2017. – stenda ziņojums
2. O. Sjomina , J. Pavlova , P. Janovic, I. Kikuste , A. Vanags, I. Tolmanis, D. Rudzite , I. Polaka, I. Kojalo, I. Liepniece-Karele, S. Isajevs , D. Santare , V. Pirags, J. Pahomova , V. Dzerve , A. Erglis , M. Leja. Pepsinogen test use in detection of gastric mucosa lesions and H.pylori eradication therapy efficiency. XII International Gastric Cancer Congress. 2017. – stenda ziņojums
3. M. Leja , E. Gašenko , I. Polaka, R. Murillo, D. Bordin, A. Link, L. Garkalne , P. Malfertheiner , R. Herrero , H. Haick. HOW DO INTRENATIONAL GASTRIC CANCER PREVENTION GUIDELINES REFLECT TO CLINICAL PRACTICE GLOBALLY? XII International Gastric Cancer Congress. 2017. – stenda ziņojums
4. I.Jelovskis , G.Ancans ,L.Lauka , S.Gerkis , A.Pcolkins , V.Krumins , R. Lunins ,M.Leja, A.Sivins. Extended surgical resection in T4 gastric cancer. XII International Gastric Cancer Congress. 2017. – stenda ziņojums
5. P.Mochalski., E.Gasenko., R. Skapars., A. Sivins., V. Krumins., V. Boka., G. Shani., M. Leja., H. Haick. Volatile organic compound emission from gastric cancer tissue – the preliminary results. XII International Gastric Cancer Congress. 2017. – stenda ziņojums
6. M.Leja. H. pylori и микробиота: что мы знаем? ЦНИИГ Гастроэнтерологии «От традиций к инновациям». 2017. – mutisks ziņojums
7. M.Leja. Какова перспектива программ ск. рининга рака желудка и толстой кишки? ЦНИИГ Гастроэнтерологии «От традиций к инновациям». 2017. – mutisks ziņojums
8. A.G. Mcnicholl, O.P. Nyssen, D. S. Bordin,, M.Leja et.al. European Registry of H. Pylori. EHMSG - XXX International Workshop on Helicobacter and Microbiota in inflammation and Cancer. 2017. – mutisks ziņojums
9. C. Robles, D. Rudzite , I. Polaka, L. Tzivian, I. Kikuste, A. Vanags, S. Isajevs, I. Liepniece-Karele, S. Parshutin, J. Y. Park, R. Murillo, R. Herrero, M. Leja. USE OF PEPSINOGENS FOR IDENTIFICATION OF PRECURSOR LESIONS BY GASTRIC LOCATION AND H. PYLORI SEROSTATUS; RESULTS FROM THE GISTAR PILOT STUDY. - EHMSG - XXX International Workshop on Helicobacter and Microbiota in inflammation and Cancer. 2017. – stenda ziņojums
10. D. Rudzīte , K. Leja , I. Kikuste , A. Rūdule , R. Vangravs , D. Šantare , D. Pūpola , Ģ. Šķenders , M. Leja. Antimicrobial Susceptibility in Helicobacter pylori Isolated From Gastric Biopsies in Adult Population in Latvia. - EHMSG - XXX International Workshop on Helicobacter and Microbiota in inflammation and Cancer. 2017. – stenda ziņojums
11. E. Gasenko , S. Isajevs , M.C. Camargo , I. Polaka, G.J.A. Offerhaus , M. Gulley , I. Kojalo, A. Kirsners, J. Pavlova , O. Sjomina , C. S.Rabkin , M. Leja . Characteristics of Epstein-Barr virus-positive gastric cancer in Latvia. EHMSG - XXX International Workshop on Helicobacter and Microbiota in inflammation and Cancer. 2017. – stenda ziņojums
12. S.Krastina , I.Andina , L.Rozkalne , K.Veinberga , S.Cui , I.Kikuste , I.Tolmanis , G.Cui , J.Pokrotnieks , I.Sitikova , M.Leja . H.pylori Eradication Prescriptions and Success Rate by General Practitioners and Gastroenterologists. - EHMSG - XXX International Workshop on Helicobacter and Microbiota in inflammation and Cancer. 2017. – stenda ziņojums
13. I. Daugule,S.Skrebinska , D.Santare , S.Isajevs , I. Liepniece-Karele ,D. Rudzite , I.Kikuste , A.Vanags , I.Tolmanis , J.Atstupens , R. Murillo, J. Young-Park , R. Herrero , M.Leja . Assessment of two plasma antibody tests and faecal antigen test for detection of Helicobacter pylori in middle-aged Caucasian population with low pepsinogen levels. - EHMSG - XXX International Workshop on Helicobacter and Microbiota in inflammation and Cancer. 2017. – stenda ziņojums
14. I. Kikuste , J. Young Park , R. Murillo, S. Parshutin , I. Polaka , A. Kirsners , R.Herrero , M. Leja . Upper gastrointestinal endoscopic examination results from the GISTAR pilot study. - EHMSG - XXX International Workshop on Helicobacter and Microbiota in inflammation and Cancer. 2017. – stenda ziņojums
15. J. Pavlova , O. Sjomina , E. Gasenko , G. Ancans , A. Sivins , I. Kikuste , A. Vanags , I. Tolmanis , D. Rudzite,I. Polaka , I. Kojalo , L. Tzivian, I. Liepniece-Karele , S. Isajevs, D. Santare , M. Leja. GastroPanel performance in Caucasian patients with gastric cancer. - EHMSG - XXX International Workshop on Helicobacter and Microbiota in inflammation and Cancer. 2017. – stenda ziņojums
16. Z. Dzērve , I. Kikuste , I. Tolmanis , A. Vanags , D. Stirna, M. Leja. Prevalence of precancerous lesions in patients undergoing upper endoscopy in Latvia: a high H.pylori prevalence area. - EHMSG - XXX International Workshop on Helicobacter and Microbiota in inflammation and Cancer. 2017. – stenda ziņojums
17. M.Leja. Where Are We with Oesophago/Gastric Cancer? 2017. - SECOND ADVOCACY MASTERCLASS. World Congress on Gastrointestinal Cancer – EuropaColon – mutisks ziņojums
18. M.Leja. Sample Stability 16S and metagenomics analysis in OC-Sensor sample bottles. 2017.- Digestive Disease Week - FIT for Screening Working Group WEO CRC Screening Committee Meeting – mutisks ziņojums
19. M.Leja. Update on the GISTAR study .. and some additional activities.2017. – Digestive Disease Week - FIT for Screening Working Group WEO CRC Screening Committee Meeting – mutisks ziņojums
20. Silis V. ,Rovite V., Mezinska S., Fridmanis D., Klovins J. Irregularities in regulations : The Latvian Case. 2017. - Global Biobank Week Toward Harmony in Biobanking 2017. – stenda ziņojums
21. A.G. Mcnicholl, O.P. Nyssen, D. S. Bordin,, M.Leja et.al. Pan-European Registry on H. pylori Management (Hp-EuReg): Bacterial Resistance of 2,241 H. pylori isolates. 2017. - 25th UEG Week 2017. – mutisks ziņojums
22. A.G. Mcnicholl, O.P. Nyssen, D. S. Bordin,, M.Leja et.al. Pan-European Registry on H. pylori Management (Hp-EuReg): First-line treatments and Interim Analysis of 20,000 Patients . 2017. - 25th UEG Week 2017. – mutisks ziņojums
23. A.G. Mcnicholl, O.P. Nyssen, D. S. Bordin,, M.Leja et.al. Pan-European Registry on H. pylori Management (Hp-EuReg): Interim Analysis of 4,417 second-line treatments. 2017. - 25th UEG Week 2017. – mutisks ziņojums
24. I. Kikuste,J. Young Park,R. Murillo, S. Parshutin, I. Polaka, A. Kirsners, R. Herrero, M. Leja. Upper gastrointestinal endoscopic findings in asymptomatic healthy individuals with normal and decreased serum pepsinogens from the GISTAR pilot study. 2017. - 25th UEG Week 2017. – stenda ziņojums
25. A. Ābols, D. Šantare, R. Toleikiene, E. Zandberga , R. Vangravs, M. Takatalo-Laine, M. Palviainen, P. Siljander, M. Leja, A. Linē. THE DIAGNOSTIC VALUE OF HYPOXIA INDUDED EXOCELLULAR VESICLES IN COLORECTAL CANCER PATIENT PLASMA. 2017. - 25th UEG Week 2017. – stenda ziņojums
26. C. Robles, D. Rudzite, I. Polaka, L.rzivian, L Kikuste, A. vanags, S. Isajevs, I. Liepniece-Karele, S. parshutin, J. Young Park, R. Murillo, R. Herrero, M. Leja. PEPSINOGENS AND GASTRIN-17 FOR IDENTIFICATION OF GASTRIC CANCER PRECURSOR LESIONS: THE RESULTS FROM THE GISTAR PILOT STUDY. 2017. - 25th UEG Week 2017. – stenda ziņojums
27. V. Petkevicius, G. Dargiene, M. Leja, A. Link, L. Jonaitis, G. Kiudelis, G. Streleckiene, J. Skieceviciene, L. Kupcinskas, P. Malfertheiner, J. Kupcinskas. Role of Polymorphisms in TLR1 and PRKAA1 Genes in the Development of Atrophic Gastritis and Gastric Cancer. 2017. - 25th UEG Week 2017. – mutisks ziņojums
28. G. Streleckiene , J. Kupcinskas , S. Juzenas, R. Gedgaudas, V. Salteniene, A. Link,M. Leja, G. Kiudelis, L. Jonaitis, R. Lukosevicius, R. Inciuraite, G. Hemmrich-Stanisak,M. Hübenthal , A. Franke, P. Malfertheiner, L. Kupcinskas, J. Skieceviciene ( Role of miR-20B-5p, miR-451a-5p and miR-1468-5p in gastric cancer. 2017. - 25th UEG Week 2017. – mutisks ziņojums
29. M.Leja. Widespread use of antibiotics: The public health perspective. 2017. - 25th UEG Week 2017. - lekcija
30. M.Leja.The epidemiology of H. pylori infection and associated diseases. 2017. - 25th UEG Week 2017. - lekcija
31. M.Leja. Gut microbiota and digestive disorders: Gastric disorders. 2017. - 25th UEG Week 2017. - lekcija
32. I.Kikuste, Z.Dzērve, I. Tolmanis, A.Vanags, D.Stirna, M.Leja. KUŅĢA PIRMSVĒŽA STĀVOKĻU IZPLATĪBA LATVIJAS PACIENTU POPULĀCIJĀ.2017. – Latvijas Ārstu Kongress. – stenda ziņojums
Key abstracts at national-level symposiums, conferences, and congresses
1. A. Urķe, P. Kriķe, Z. Shums, D. Rudzīte, I. Poļaka, A. Sīviņš, I. Jelovskis, S. Isajevs, I. Bogdanova, V. Boka, U. Vikmanis, G. L Norman, M. Leja. THE PREVALENCE OF ANTI-PARIETAL CELL AND INTRINSIC FACTOR ANTIBODIES IN PATIENTS WITH GASTRIC ADENOCARCINOMA. 2017. - Latvijas Universitātes 75. zinātniskā konference. Medicīnas sekcija. – mutisks ziņojums
2. D. Rudzīte, K. Leja, I. Ķikuste, A. Rūdule, R. Vangravs, D. Šantare, Ģ. Šķenders, M. Leja. ANTIMICROBIAL RESISTANCE IN HELICOBACTER PYLORI ISOLATED FROM GASTRIC BIOPSIES IN ADULT POPULATION IN LATVIA. 2017. - Latvijas Universitātes 75. zinātniskā konference. Medicīnas sekcija. – mutisks ziņojums
3. D. Šantare, I. Kojalo, M. Leja. COMPARISON OF OVERALL TEST POSITIVITY AND GENDER DIFFERENCES OF FAECAL IMMUNOCHEMICALTEST RESULTS. 2017. - Latvijas Universitātes 75. zinātniskā konference. Medicīnas sekcija. – mutisks ziņojums
4. K. Purmalis, J. Priede, D. Santare, I. Kojalo, M. Leja. GASTRIC CANCER SCREENING COST EFFICIENCY ANALYSES USING BIOMARKERS . 2017. - Latvijas Universitātes 75. zinātniskā konference. Medicīnas sekcija. – mutisks ziņojums
5. M. Melnalksne, J. Gabriella Mohova, M.Tatičeka, A. Tupīte, S. Isajevs, M. Leja, A. Linē. ASSOCIATION OF INTRATUMORAL INFILTRATING LYMPHOCYTES WITH THE DEGREE OF DIFFERENTIATION AND GROWTH PATTERN OF GASTRIC CARCINOMA. 2017. - Latvijas Universitātes 75. zinātniskā konference. Medicīnas sekcija. – mutisks ziņojums
6. P. Kriķe, Z. Shums, D. Rudzīte, I. Polaka, S. Isajevs, G. L Norman, M. Leja. THE PREVALENCE OF ANTI-PARIETAL CELL AND ANTI-INTRINSIC FACTOR ANTIBODIES, PEPSINOGENS, GASTRIN-17 AND H.PYLORI INFECTION IN CORPUS-RESTRICTED GASTRITIS PATIENTS. 2017. - Latvijas Universitātes 75. zinātniskā konference. Medicīnas sekcija. – mutisks ziņojums