A new scientific paper on serological biomarker (anti-parietal cell antibodies and anti-intrinsic factor antibodies) value in non invasive diagnostics of autoimmune gastritis has been published in the Open Access Journal from MDPI ‘Diagnostics’:

The diagnostic value of anti-parietal cell and intrinsic factor antibodies, pepsinogens, and gastrin-17 in corpus restricted atrophic gastritis

The study suggests that the best combination of non-invasive biomarkers for detecting autoimmune gastritis is the combination of pepsinogen I/II ratio and anti- parietal cell antibodies. Autoimmune gastritis is localized in corpus part and is linked to increased gastric cancer risk.

The authors of the publication are the Pauls Stradiņš Clinical University Hospital’s internist, immunologist Petra Kriķe, the article was prepared under the guidance of UL professor, gastroenterologist, UL ICPM director Mārcis Leja, among the authors are UL ICPM researchers Inese Poļaka, Daiga Šantare, Lilian Tzivian, as well as GASTRO representatives Ilze ķikuste, Ivars Tolmanis, Aigars Vanags, and Sergej Isajevs from the Academic Histology Laboratory, Inta Liepniece-Karele from the Rīga Stradiņš University Department of Pathology, Dace Rudzīte from Riga East Clinical University Hospital, together with employees of the National Cancer Institute (USA) Minkyo Song, M. Constanza Camargo and Gary L Norman and Zakera Shums from the USA laboratory diagnostics company ‘Werfen’.

The study was conducted using the material collected by the Digestive Diseases Center GASTRO and developed in cooperation with the Digestive Diseases Center GASTRO, Academic Histology Laboratory, laboratory examinations were performed with the support of the diagnostic companies ‘Werfen’ (USA) and ‘Biohit’ (Finland).

The article is openly accessible on ‘Diagnostics’: https://www.mdpi.com/2075-4418/12/11/2784

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