2017


 Internationally cited publications

Publications included in worldwide quotation index lists​ (PubMed, Scopus, Web of Science, Google Scholar, etc.)

1. Nakhleh M. K., Amal H., Jeries R., Broza Y., M Aboud … Leja M. Diagnosis and Classification of 17 Diseases from 1404 Subjects via Pattern Analysis of Exhaled Molecules. ACS Nano. 2017;Jan 24;11(1):112-125.

2. Leja M, Camargo M.C., Polaka I., Isajevs S., Liepniece-Karele I., Janciauskas D., Rudzite D., Kikuste I., Vanags A., Kojalo I., Folkmanis V., Kirsners A., ... [et al.] Detection of gastric atrophy by circulating pepsinogens: A comparison of three assays. Helicobacter. 2017;22(4).

3. Petkevicius V., Salteniene V., Juzenas S., Wex T., Link A., Leja M., Steponaitiene R., Skieceviciene J., Kupcinskas L., Jonaitis L., Kiudelis G., Malfertheiner P., Kupcinskas J. Polymorphisms of microRNA target genes IL12B, INSR, CCND1 and IL10 in gastric Cancer. World Journal of Gastroenterology. 2017; 23(19): 3480-3487.

4. 2015 European Society of Coloproctology collaborating group; Leja M, et.al. The relationship between method of anastomosis and anastomotic failure after right hemicolectomy and ileo-caecal resection: an international snapshot audit. Colorectal Disease. 2017; 19(8): e296-e311

5. Kontsevaya I., Nikolayevskyy V., Kovalyov A., Ignatyeva O., Sadykhova A., Simak T., Tikhonova O., Dubrovskaya Y., Vasiliauskiene E., Davidaviciene E., Skenders G., Makurina O., Balabanova Y., Drobniewski F. Tuberculosis cases caused by heterogeneous infection in Eastern Europe and their influence on outcomes. Journal of molecular epidemiology and evolutionary genetics in infectious diseases. MEEGID .2017; 48:76-82

6. Malfertheiner P., Megraud F., Leja M, et.al. Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report. Gut.2017. 66(1):6-30.

7. Meistere I., Werner S., Zayakin P., Siliņa K., Rulle U., Pismennaja A., Šantare D., Kikuste I., Isajevs S., Leja M., Kupčinskas L., Kupčinskas J., Jonaitis L., Wu CY., Brenner H., Linē A., Kalniņa Z. The Prevalence of Cancer-Associated Autoantibodies in Patients with Gastric Cancer and Progressive Grades of Premalignant Lesions. Cancer Epidemiol. Biomarkers Prev. 2017. 26(10):1564-1574.

8. Leja M., Park JY., Murillo R., Liepniece-Karele I., Isajevs S., Kikuste I., Rudzite D., Krike P., Parshutin S., Polaka I., Kirsners A., Santare D., Folkmanis V., Daugule I., Plummer M., Herrero R. Multicentric randomised study of Helicobacter pylori eradication and pepsinogen testing for prevention of gastric cancer mortality: the GISTAR study. BMJ Open.2017. 7(8):e016999.

9. Gudra D., Fridmanis D.,  Klovins J.,  Skenders G.,  Silamikelis I., Radovica-Spalvina I.,  Peculis R.,  Kalnina  i., Elbere I.,  Hultcrantz R., Leja M., Engstrand L. FIT test-systems for mega-scale gut microbiome testing. Annals of Oncology, Volume 28, Issue suppl_3, 1 June 2017, mdx261.032, https://doi.org/10.1093/annonc/mdx261.032

10.  Sjomina O., Heluwaert F., Moussata D., Leja M. Helicobacter pylori infection and nonmalignant diseases. PMID: 28891136 DOI: 10.1111/hel.12408


 Publications in Latvian scientific issues

  LZA Vēstis, and others

1.   Leja M. Helikobaktērija - draugs vai ienaidnieks? Latvijas Ārsts, 2017: decembris, 34-39. 

2. Leja M., Lašina I., Šitikova I., Krastiņa S., Petkeviča Ģ. Cik pareizi H.pylori eradikācijas terapiju izvēlas Latvijas ģimenes ārsti un gastroenterologi? Latvijas Ārsts, 2017: decembris, 40-44.  Coefficient Values in Collapsed and Distended Small Bowel Loops and their Potential Importance for excluding Inflammatory Bowel Disease: A Study in Health Subjects. Acta Chirurgica Latviensis, 2016: 1, 23-30. 


 The most important theses at international conferences

1. M. Leja , A. Rudule , J. Young Park , R. Murillo, I. Liepniece-Karele , S. Isajevs  , I. Kikuste, D. Rudzite, P.Krike, S. Parshutin, I. Polaka, A. Kirsners , D. Santare, I. Daugule , R. Herrero. Multicentric randomized study of H. pylori eradication and pepsinogen testing for prevention of gastric cancer mortality (GISTAR): preliminary results of the pilot.  XII  International Gastric Cancer Congress.  2017. – stenda ziņojums

2. O. Sjomina , J. Pavlova , P. Janovic, I. Kikuste , A. Vanags, I. Tolmanis, D. Rudzite , I. Polaka, I. Kojalo, I. Liepniece-Karele, S.  Isajevs  , D. Santare , V. Pirags, J. Pahomova , V. Dzerve , A. Erglis , M. Leja. Pepsinogen test use in detection of gastric mucosa lesions and H.pylori eradication therapy efficiency. XII  International Gastric Cancer Congress.  2017. – stenda ziņojums

3. M. Leja , E. Gašenko , I. Polaka, R. Murillo, D. Bordin, A. Link, L. Garkalne , P. Malfertheiner , R. Herrero , H. Haick. HOW DO INTRENATIONAL GASTRIC CANCER PREVENTION GUIDELINES REFLECT TO CLINICAL PRACTICE GLOBALLY? XII  International Gastric Cancer Congress.  2017. – stenda ziņojums

4. I.Jelovskis , G.Ancans ,L.Lauka , S.Gerkis , A.Pcolkins , V.Krumins , R. Lunins ,M.Leja, A.Sivins.  Extended surgical resection in T4 gastric cancer. XII  International Gastric Cancer Congress.  2017. – stenda ziņojums

5. P.Mochalski., E.Gasenko., R. Skapars., A. Sivins., V. Krumins., V. Boka., G. Shani., M. Leja., H. Haick. Volatile organic compound emission from gastric cancer tissue – the preliminary results. XII  International Gastric Cancer Congress.  2017. – stenda ziņojums

6. M.Leja. H. pylori и микробиота: что мы знаем? ЦНИИГ Гастроэнтерологии «От традиций к инновациям». 2017. – mutisks ziņojums

7. M.Leja. Какова перспектива программ ск. рининга рака желудка и толстой кишки? ЦНИИГ Гастроэнтерологии «От традиций к инновациям». 2017. – mutisks ziņojums

8. A.G. Mcnicholl, O.P. Nyssen, D. S. Bordin,, M.Leja  et.al.  European Registry of H. Pylori. EHMSG -  XXX International Workshop on Helicobacter and Microbiota in inflammation and Cancer. 2017. – mutisks ziņojums

9. C. Robles, D. Rudzite , I. Polaka, L. Tzivian, I. Kikuste, A. Vanags, S. Isajevs, I.

Liepniece-Karele, S. Parshutin, J. Y. Park, R. Murillo, R. Herrero, M. Leja. USE OF PEPSINOGENS FOR IDENTIFICATION OF PRECURSOR LESIONS BY GASTRIC LOCATION AND H. PYLORI SEROSTATUS; RESULTS FROM THE GISTAR PILOT STUDY. - EHMSG -  XXX International Workshop on Helicobacter and Microbiota in inflammation and Cancer. 2017. – stenda ziņojums

10. D. Rudzīte  , K. Leja , I. Kikuste , A. Rūdule  , R. Vangravs , D. Šantare , D. Pūpola , Ģ. Šķenders , M. Leja. Antimicrobial Susceptibility in Helicobacter pylori Isolated From Gastric Biopsies in Adult Population in Latvia. - EHMSG -  XXX International Workshop on Helicobacter and Microbiota in inflammation and Cancer. 2017. – stenda ziņojums                                                                                                                                                          

11. E. Gasenko , S. Isajevs , M.C. Camargo , I. Polaka, G.J.A. Offerhaus  , M. Gulley , I. Kojalo, A. Kirsners, J. Pavlova , O. Sjomina , C. S.Rabkin , M. Leja . Characteristics of Epstein-Barr virus-positive gastric cancer in Latvia. EHMSG -  XXX International Workshop on Helicobacter and Microbiota in inflammation and Cancer. 2017. – stenda ziņojums

12. S.Krastina  , I.Andina  , L.Rozkalne , K.Veinberga , S.Cui , I.Kikuste , I.Tolmanis , G.Cui , J.Pokrotnieks  , I.Sitikova , M.Leja . H.pylori Eradication Prescriptions and Success Rate by General Practitioners and Gastroenterologists. - EHMSG -  XXX International Workshop on Helicobacter and Microbiota in inflammation and Cancer. 2017. – stenda ziņojums

13. I. Daugule,S.Skrebinska  , D.Santare , S.Isajevs  , I. Liepniece-Karele  ,D. Rudzite , I.Kikuste  , A.Vanags  , I.Tolmanis , J.Atstupens , R. Murillo, J. Young-Park , R. Herrero , M.Leja . Assessment of two plasma antibody tests and faecal antigen test for detection of Helicobacter pylori in middle-aged Caucasian population with low pepsinogen levels. - EHMSG -  XXX International Workshop on Helicobacter and Microbiota in inflammation and Cancer. 2017. – stenda ziņojums

14. I. Kikuste , J. Young Park , R. Murillo, S. Parshutin , I. Polaka , A. Kirsners , R.Herrero , M. Leja . Upper gastrointestinal endoscopic examination results from the GISTAR pilot study. - EHMSG -  XXX International Workshop on Helicobacter and Microbiota in inflammation and Cancer. 2017. – stenda ziņojums

15. J. Pavlova , O. Sjomina  , E. Gasenko , G. Ancans , A. Sivins , I. Kikuste , A. Vanags , I. Tolmanis , D. Rudzite,I. Polaka , I. Kojalo , L. Tzivian, I. Liepniece-Karele , S. Isajevs, D. Santare , M. Leja. GastroPanel performance in Caucasian patients with gastric cancer. - EHMSG -  XXX International Workshop on Helicobacter and Microbiota in inflammation and Cancer. 2017. – stenda ziņojums

16. Z. Dzērve , I. Kikuste , I.  Tolmanis , A. Vanags , D. Stirna, M. Leja. Prevalence of precancerous lesions in patients undergoing upper endoscopy in Latvia: a high H.pylori prevalence area. - EHMSG -  XXX International Workshop on Helicobacter and Microbiota in inflammation and Cancer. 2017. – stenda ziņojums

17. M.Leja. Where Are We with Oesophago/Gastric Cancer? 2017. - SECOND ADVOCACY MASTERCLASS. World Congress on Gastrointestinal Cancer – EuropaColon – mutisks ziņojums

18. M.Leja. Sample Stability 16S and metagenomics analysis in OC-Sensor sample bottles. 2017.- Digestive Disease Week - FIT for Screening Working Group WEO CRC Screening Committee Meeting – mutisks ziņojums

19. M.Leja. Update on the GISTAR study .. and some additional activities.2017. – Digestive Disease Week - FIT for Screening Working Group WEO CRC Screening Committee Meeting – mutisks ziņojums

20. Silis V. ,Rovite V., Mezinska S., Fridmanis D., Klovins J. Irregularities in regulations : The Latvian Case. 2017. - Global Biobank Week Toward Harmony in Biobanking 2017. – stenda ziņojums

21. A.G. Mcnicholl, O.P. Nyssen, D. S. Bordin,, M.Leja  et.al.  Pan-European Registry on H. pylori Management (Hp-EuReg): Bacterial Resistance of 2,241 H. pylori isolates. 2017. - 25th UEG Week 2017. – mutisks ziņojums

22. A.G. Mcnicholl, O.P. Nyssen, D. S. Bordin,, M.Leja  et.al.  Pan-European Registry on H. pylori Management (Hp-EuReg): First-line treatments and Interim Analysis of 20,000 Patients . 2017. - 25th UEG Week 2017. – mutisks ziņojums

23. A.G. Mcnicholl, O.P. Nyssen, D. S. Bordin,, M.Leja  et.al.  Pan-European Registry on H. pylori Management (Hp-EuReg): Interim Analysis of 4,417 second-line treatments. 2017. - 25th UEG Week 2017. – mutisks ziņojums

24. I. Kikuste,J.  Young Park,R.  Murillo, S. Parshutin, I. Polaka, A.  Kirsners, R. Herrero, M. Leja. Upper gastrointestinal endoscopic findings in asymptomatic healthy individuals with normal and decreased serum pepsinogens from the GISTAR pilot study. 2017. - 25th UEG Week 2017. – stenda ziņojums

25. A. Ābols, D. Šantare, R. Toleikiene, E. Zandberga , R. Vangravs, M. Takatalo-Laine, M. Palviainen, P. Siljander, M. Leja, A. Linē. THE DIAGNOSTIC VALUE OF HYPOXIA INDUDED EXOCELLULAR VESICLES IN COLORECTAL CANCER PATIENT PLASMA. 2017. - 25th UEG Week 2017. – stenda ziņojums

26. C. Robles, D. Rudzite, I. Polaka, L.rzivian, L Kikuste, A. vanags, S. Isajevs, I. Liepniece-Karele, S. parshutin, J. Young Park, R. Murillo, R. Herrero, M. Leja. PEPSINOGENS AND GASTRIN-17 FOR IDENTIFICATION OF GASTRIC CANCER PRECURSOR LESIONS: THE RESULTS FROM THE GISTAR PILOT STUDY. 2017. - 25th UEG Week 2017. – stenda ziņojums

27. V. Petkevicius, G. Dargiene, M. Leja, A. Link, L. Jonaitis, G. Kiudelis, G. Streleckiene, J. Skieceviciene, L. Kupcinskas, P. Malfertheiner, J. Kupcinskas.  Role of Polymorphisms in TLR1 and PRKAA1 Genes in the Development of Atrophic Gastritis and Gastric Cancer. 2017. - 25th UEG Week 2017. – mutisks ziņojums

28. G. Streleckiene , J. Kupcinskas , S. Juzenas, R. Gedgaudas, V. Salteniene, A. Link,M. Leja, G. Kiudelis, L. Jonaitis, R. Lukosevicius, R. Inciuraite, G. Hemmrich-Stanisak,M. Hübenthal , A. Franke, P. Malfertheiner, L. Kupcinskas, J. Skieceviciene ( Role of miR-20B-5p, miR-451a-5p and miR-1468-5p in gastric cancer. 2017. - 25th UEG Week 2017. – mutisks ziņojums

29. M.Leja. Widespread use of antibiotics: The public health perspective. 2017. - 25th UEG Week 2017. - lekcija

30. M.Leja.The epidemiology of H. pylori infection and associated diseases. 2017. - 25th UEG Week 2017. - lekcija

31. M.Leja. Gut microbiota and digestive disorders: Gastric disorders. 2017. - 25th UEG Week 2017. - lekcija

32. I.Kikuste, Z.Dzērve, I. Tolmanis, A.Vanags, D.Stirna, M.Leja. KUŅĢA PIRMSVĒŽA STĀVOKĻU IZPLATĪBA LATVIJAS PACIENTU POPULĀCIJĀ.2017. – Latvijas Ārstu Kongress. – stenda ziņojums


 The most important theses at the national level are symposiums, conferences, congresses

1. A. Urķe, P. Kriķe, Z. Shums, D. Rudzīte, I. Poļaka, A. Sīviņš, I. Jelovskis, S. Isajevs,  I. Bogdanova, V.  Boka, U. Vikmanis, G. L Norman, M. Leja. THE PREVALENCE OF ANTI-PARIETAL CELL AND INTRINSIC FACTOR ANTIBODIES IN PATIENTS WITH GASTRIC ADENOCARCINOMA. 2017. - Latvijas Universitātes 75. zinātniskā konference. Medicīnas sekcija. – mutisks ziņojums

2. D. Rudzīte, K. Leja, I. Ķikuste, A. Rūdule, R. Vangravs, D. Šantare, Ģ. Šķenders, M. Leja. ANTIMICROBIAL RESISTANCE IN HELICOBACTER PYLORI ISOLATED FROM GASTRIC BIOPSIES IN ADULT POPULATION IN LATVIA. 2017. - Latvijas Universitātes 75. zinātniskā konference. Medicīnas sekcija. – mutisks ziņojums

3. D. Šantare, I. Kojalo, M. Leja. COMPARISON OF OVERALL TEST POSITIVITY AND GENDER DIFFERENCES OF FAECAL IMMUNOCHEMICALTEST RESULTS. 2017. - Latvijas Universitātes 75. zinātniskā konference. Medicīnas sekcija. – mutisks ziņojums

4. K. Purmalis, J. Priede, D. Santare, I. Kojalo, M. Leja. GASTRIC CANCER SCREENING COST EFFICIENCY ANALYSES USING BIOMARKERS . 2017. - Latvijas Universitātes 75. zinātniskā konference. Medicīnas sekcija. – mutisks ziņojums

5. M. Melnalksne, J. Gabriella Mohova, M.Tatičeka, A. Tupīte, S. Isajevs, M. Leja, A. Linē. ASSOCIATION OF INTRATUMORAL INFILTRATING LYMPHOCYTES WITH THE DEGREE OF DIFFERENTIATION AND GROWTH PATTERN OF GASTRIC CARCINOMA. 2017. - Latvijas Universitātes 75. zinātniskā konference. Medicīnas sekcija. – mutisks ziņojums

6. P. Kriķe, Z.  Shums, D. Rudzīte, I. Polaka, S. Isajevs, G. L Norman, M. Leja. THE PREVALENCE OF ANTI-PARIETAL CELL AND ANTI-INTRINSIC FACTOR ANTIBODIES, PEPSINOGENS, GASTRIN-17 AND H.PYLORI INFECTION IN CORPUS-RESTRICTED GASTRITIS PATIENTS. 2017. - Latvijas Universitātes 75. zinātniskā konference. Medicīnas sekcija. – mutisks ziņojums

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